New Recommendations for Economic Analysis of Vaccination Programs

ISPOR Good Practices for Outcomes Research Provide Guidance for High-, Middle-, and Low-Income Countries

 Lawrenceville, NJ, USA—October 23, 2018—ISPOR—the professional society for health economics and outcomes research, announced today the publication of new recommendations for economic analysis of vaccination programs given limited resources and budgets. The recommendations, issued by the ISPOR Economic Evaluation of Vaccines Designed to Prevent Infectious Disease: Good Practices Task Force, are applicable to countries of various income levels. The report, Economic Analysis of Vaccination Programs: An ISPOR Good Practices for Outcomes Research Task Force Report: An ISPOR Good Practices for Outcomes Research Task Force Report, was published in the October 2018 issue of Value in Health.

The Task Force report provides good practice recommendations for 3 specific analysis methods—cost-effectiveness analysis, constrained optimization modeling, and fiscal health modeling—to assess the economic impact of vaccination and comparator programs to inform decision makers and budget holders. These 3 approaches are useful to decision makers with different policy objectives working in different decision contexts and the recommendations are applicable to high-, middle-, and low-income countries. These complementary methodological approaches can offer an integrated economic perspective of a new vaccination program’s value in a useful format for meeting policy objectives based on the best available evidence.

The report presents 14 categories of best-practice recommendations and explanatory information for cost-effectiveness analysis, constrained optimization modeling, and fiscal health modeling. The recommendations are grouped into 4 main topics:

  • Decision description (policy objective, decision context and perspective)
  • Disease modeling approaches (model structure, time horizon, comparators, data requirements and sources, outcome measures)
  • Data evaluation (analysis method and interpretation, discount rates, uncertainty analysis, validation)
  • Logistics (software, transparency, reporting)

“Our recommendations take a global perspective where the decision maker, along with the policy objective and decision context, determine which method(s) to use and how to operationalize each method and identify the input data needed,” said Task Force co-chair Josephine Mauskopf, PhD, Vice President, Health Economics, RTI Health Solutions, NC, USA. “This report does not propose normative rules that identify desirable policy objectives or recommend specific methods to achieve each policy objective. However, decision makers in different decision contexts can use the best practices for the analyses described in this report to make sound decisions about a vaccination program.”



ISPOR, the professional society for health economics and outcomes research (HEOR), is an international, multistakeholder, nonprofit dedicated to advancing HEOR excellence to improve decision making for health globally. The Society is the leading source for scientific conferences, peer-reviewed and MEDLINE®-indexed publications, good practices guidance, education, collaboration, and tools/resources in the field.
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ISPOR has earned an international reputation for research excellence based, in part, on its Good Practices for Outcomes Research Task Force Reports. These highly cited reports are expert consensus recommendations on good practice standards for outcomes research (clinical, economic, and patient-reported outcomes) and on the use of this research in healthcare decision making. ISPOR Task Forces comprise subject matter experts representing different stakeholders from diverse work environments (ie, researchers and academicians, assessors and regulators, payers and policy makers, the life sciences industry, and patient engagement organizations around the world). All ISPOR Good Practices for Outcomes Research Reports are published in the Society’s scientific journal, Value in Health, and are made freely available as part of the Society’s mission. The Society’s Good Practices for Outcomes Research Reports have been recognized with an ASAE “Power of A” award that acknowledges innovative, effective, and broad-reaching programs that have a positive impact on the world.

Value in Health (ISSN 1098-3015) is an international, indexed journal that publishes original research and health policy articles that advance the field of health economics and outcomes research to help healthcare leaders make evidence-based decisions. The journal’s 2017 impact factor score is 5.494. Value in Health is ranked 3rd among 94 journals in healthcare sciences and services, 3rd among 79 journals in health policy and services, and 6th among 353 journals in economics. Value in Health is a monthly publication that circulates to more than 10,000 readers around the world.
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