Category: Methodological Articles

As the name implies, these papers deal with methodological issues in any of the topic areas within the scope of the journal. They can include data if these are required to illustrate the importance of particular methodological points.

A Case Study Of Surrogate Outcomes For Overall Survival In The Treatment Of Chronic Myelogenous Leukemia

Exeter, UK – Ideally, licensing and value-for-money policy decisions on medications should be based on clinical trials that show benefits to final patient health outcomes, such as overall survival.  In order to speed up the approval process, however, those decisions often

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Validating A Cardiovascular Risk Tool For Use In A Contemporary Diabetes Population

Cambridge, UK – Originally derived from a group of diabetes patients recruited from the 1970s to the 1990s, the UKPDS outcomes model is a widely-used risk tool for predicting cardiovascular outcomes, such as heart attack and stroke, in patients with diabetes.

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Expecting A Lot Of Missing Data In Your Resource Use Questionnaire? Give Patients A Resource Use Log Too!

Bristol, UK – Using patient-completed questionnaires to collect resource use in economic evaluations conducted alongside randomised controlled trials (RCTs) often results in missing data. A research team from the University of Bristol designed a log to give patients at baseline so

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New Approach To “Mapping” Treatment Effects To Generic Health-Related Quality Of Life Scales

Bristol, UK – “The benefits of new treatments in improving quality of life have been routinely under-estimated.” That is the conclusion from the first of two papers by Lu, Ades et al. from the University of Bristol. In the paper, “Mapping from

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Recommendations For Estimating Utility Values From Other Health Measures

Sheffield, UK – Decision-making agencies, such as the National Institute for Health and Clinical Excellence (NICE) in the UK, recommend the inclusion of utility data in health technology assessments, and sometimes require data to be collected using specific patient-reported outcome measures

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Innovative Methods Uncover Differential Responders To Treatment

Manchester, UK – Variability in response to treatment (also called heterogeneity of treatment effects) is a common finding in clinical trials. Some variability is hypothesised and expected, such as differences between treatment and placebo groups, across doses, or between comparator drugs.

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New Statistical Method Provides Timely Comparative Effectiveness Research

Boston, MA, USA – Health care companies face increased pressure to compare the effectiveness of new treatments as early as possible. A study published in Value in Health reports on a novel statistical method that can be used to compare approved treatments even

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Research Shows How To Avoid Misleading With Statistics

Ann Arbor, MI, USA – Research conducted by the University of Michigan School of Public Health shows that when researchers compare two or more treatments, the choice of how to express results may affect their conclusion about which is best.

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