Category: Methodological Articles

As the name implies, these papers deal with methodological issues in any of the topic areas within the scope of the journal. They can include data if these are required to illustrate the importance of particular methodological points.

STUDY FINDS BEST-WORST SCALING COMPARABLE TO DISCRETE CHOICE EXPERIMENT IN ESTIMATING PATIENT PREFERENCES

However, Risk Tolerance Thresholds Differ Between the Two Methods Princeton, NJ—July 25, 2016—The International Society for Pharmacoeconomics and Outcomes Research (ISPOR) announced today the publication of a study comparing the metrics obtained from profile-case best-worst scaling (BWS) with those from

Posted in Announcements, ISPOR Journals, ISPOR News & Press, Methodological Articles, Value in Health Tagged with: , , , ,

MAPPING THE CLINICAL COPD QUESTIONNAIRE ONTO EQ-5D VALUES

Rotterdam, The Netherlands – The Clinical COPD Questionnaire (CCQ) is a widely-used questionnaire to assess the effectiveness of chronic obstructive pulmonary disease (COPD) treatments. However, it is not a preference-based measure, and hence cannot be directly used to estimate the

Posted in Announcements, Methodological Articles, Value in Health Tagged with: , , , , , , ,

CURRENT PRACTICE OF RCT-BASED MODELLING CAN LEAD TO WRONG RESEARCH PRIORITIES

Rotterdam, The Netherlands – The current practice of prioritizing research in the context of conditional reimbursement can lead to wrong decisions since it relies on randomized controlled trials (RCT) based cost-effectiveness models, which do not reflect all uncertainties that are

Posted in Methodological Articles, Value in Health Tagged with: , , , , ,

HOW DO WE IMPROVE MODELS THAT ARE NAÏVE TO REAL-WORLD ADHERENCE?

Seattle, WA, USA – Clinical trial patients often exhibit high medication adherence. But what happens in the real world? Medication adherence in routine practice is often lower and the effectiveness may differ. Models used to evaluate the cost- and comparative

Posted in Methodological Articles, Value in Health Tagged with: , , ,

Meta-Analysis Is Not Appropriate for Burden of Disease Estimates

Brisbane, Australia – In burden of disease studies, decisions about the pooling of estimates, such as prevalence across countries, are largely made using conventional meta-analysis models. However, when there is true diversity and dissimilarity of effects, meta-analysis is not recommended. If

Posted in Methodological Articles, Value in Health Tagged with: , , , ,

Drug Initiation: Major Issue In Long-Term Adherence To Medication Therapy

Gentofte, Denmark – Poor adherence to long-term medication therapy among patients with a chronic disease is well-known, but the nature of poor adherence over time, at a population level is not well established. Studies from clinical trials have shown that discontinuation is

Posted in Methodological Articles, Value in Health Tagged with: , ,

Linking Profile To Preference-Based Measures – Don’t Regress

Aberdeen, UK & Los Angeles, CA, USA – Health-related quality of life measures can provide useful information to decision makers involved in health care resource allocation.  These decision makers are concerned with the planning of health care services and are often interested

Posted in Methodological Articles, Value in Health Tagged with: , , , , , , ,

The QALY Model Upside-Down

Leiden, The Netherlands – The quality-adjusted life years (QALY) model is defined, in its most basic form, as life duration multiplied by an index in the 0-1 range representing the patients’ quality-of-life. The hazard function is a key concept in the statistical

Posted in Methodological Articles, Value in Health Tagged with: , , , ,

Bayesian Meta-Analysis Of Diverse Sources Of Evidence Can Expedite Health Technology Assessments

Leicester, United Kingdom – In health technology assessment, decisions about the availability of new health technologies within a national health service are largely based on effectiveness estimates. Variability in reported outcomes measured by alternative instruments, or extended follow-up time of clinical

Posted in Methodological Articles, Value in Health Tagged with: , , , , ,